Dr David Riglar’s research aims to better understand the function of the gut and its resident microbiota during health and disease using a combination of synthetic biology, imaging and sequencing-based approaches. In particular, David is interested in how bacteria function differently in different regions of the gut.

The microbes that live in our guts are essential for
maintaining our health. Changes to the make-up and function of the microbiota
have been associated with a wide range of diseases including inflammatory bowel
disease, colorectal cancer, diabetes and neurodevelopmental disorders.

Because of the intimate relationship they have with their
surroundings, our microbes can be used to gain new insights into the gut and
could one day diagnose, monitor and treat disease in the clinic. To this end,
David’s lab is developing innovative technologies using engineered bacteria to
probe and control the gut environment.